Authored by Nitesh

Blog Images 2023 07 10T002650.638 2
Blog Images 2023 07 10T002650.638 2

Welcome to Karkhana.io, your trusted partner in flexible and scalable manufacturing solutions for the pharmaceutical industry. In this blog, we will delve into the science behind tablet picking and sticking, addressing common challenges and exploring innovative solutions. Discover how Karkhana.io can provide tailored manufacturing solutions to enhance tablet production efficiency.

Understanding Tablet Picking and Sticking

Tablet picking and sticking are common issues encountered during tablet manufacturing. Picking refers to the undesired adhesion of tablets to the surfaces of equipment, while sticking refers to the tablets sticking together. These issues can lead to production downtime, product defects, and compromised quality.

The occurrence of picking and sticking is influenced by various factors, including tablet formulation, equipment design, and processing conditions. Understanding the underlying science is crucial for implementing effective strategies to mitigate these issues.

Key Factors Affecting Tablet Picking and Sticking

  1. Formulation: Tablet composition, including the choice of excipients, can significantly impact picking and sticking. Factors such as the presence of hygroscopic materials, improper lubrication, and formulation incompatibilities can contribute to these issues.
  2. Equipment Design: The design and surface properties of tablet compression equipment play a critical role in preventing picking and sticking. Smooth and polished surfaces, appropriate coatings, and the use of anti-sticking materials can help minimize adhesion.
  3. Processing Conditions: Tablet manufacturing processes, including compression force, dwell time, and speed, can influence tablet picking and sticking. Optimal process parameters should be determined to achieve proper tablet formation without compromising integrity.

Innovative Solutions for Tablet Picking and Sticking

  1. Surface Modification: Implementing surface modifications on tablet compression equipment can reduce adhesion. Techniques such as plasma treatment, coatings, and textured surfaces can improve tablet release characteristics and minimize sticking.
  2. Improved Lubrication: Proper lubrication of tablet formulations is essential to prevent picking and sticking. Utilizing advanced lubrication techniques, such as dry lubrication or lubricant blends, can enhance tablet flow properties and reduce adhesion.
  3. Material Selection: Choosing appropriate excipients with anti-sticking properties can help address picking and sticking issues. These excipients can provide a barrier between tablets and equipment surfaces, minimizing adhesion.

Karkhana.io’s Expertise in Tablet Manufacturing

Tablet picking and sticking are common challenges in tablet manufacturing that can impact productivity and product quality. Understanding the science behind these issues and implementing innovative solutions is crucial for successful tablet production. Partner with Karkhana.io to access tailored manufacturing solutions and overcome these challenges. 

At Karkhana.io, we understand the complexities of tablet manufacturing and the challenges posed by picking and sticking. With our extensive network of certified suppliers and expertise in core manufacturing processes, we offer high-quality tablet tooling dies & punches. 

With Karkhana.io, you gain a strategic advantage in tablet manufacturing. Contact us today to leverage our expertise and drive efficiency and excellence in your tablet production.

Fill out the form below to explore how Karkhana.io’s capabilities can revolutionize your tablet production.